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Article

Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways.

Genes & development - 15 Jan 2014

Ogawa Hiroyasu, Kozhemyakina Elena, Hung Han-Hwa, Grodzinsky Alan J, Lassar Andrew B

Abstract excerpt

Lubricin is a secreted proteoglycan encoded by the Prg4 locus that is abundantly expressed by superficial zone articular chondrocytes and has been noted to both be sensitive to mechanical loading and protect against the development of osteoarthritis. In this study, we document that running induces maximal expression of Prg4 in the superficial zone of knee joint articular cartilage in a COX-2-dependent fashion,...

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Topics

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Share to Adenosine Triphosphate
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chondrocytes

Share to CREB-Binding Protein

Share to Gene Knockdown Techniques

Share to Motor Activity

Share to Proteoglycans

Share to Stress, Physiological

Source

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Identifiers

PMID: 24449269
DOI: 10.1101/gad.231969.113
PMCID: PMC3909787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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