Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3

1 Nov 2021

Abstract excerpt

PURPOSE: Osteoarthritis (OA) is a common disease for human beings, characterized by severe inflammation, cartilage degradation, and subchondral bone destruction. However, current therapies are limited to relieving pain or joint replacement and no effective treatment methods have been discovered to improve degenerative changes. Currently, a variety of evidences have indicated that aberrant mechanical stimuli is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connective Tissue Growth Factor Research
Share to Osteoarthritis Treatment and Mechanisms
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34824542
DOI: 10.2147/jir.s339382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3PMID 34824542Read ↗

Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoidsSemantic proximity Read ↗

Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damageSemantic proximity Read ↗

Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1Semantic proximity Read ↗

Epigenetic Dynamics in Meniscus Cell Migration and its Zonal Dependency in Response to Inflammatory Conditions: Implications for Regeneration StrategiesSemantic proximity Read ↗

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signalingSemantic proximity Read ↗

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signalingSemantic proximity Read ↗

Ezh2 Ameliorates Osteoarthritis by Activating TNFSF13BSemantic proximity Read ↗

A high-impact <i>COL6A3</i> mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loadingSemantic proximity Read ↗

Epigenetic dynamics in meniscus cell migration and its zonal dependency in response to inflammatory conditionsSemantic proximity Read ↗

Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with OsteoarthritisSemantic proximity Read ↗

BuShen JianGu Fang alleviates cartilage degeneration via regulating multiple genes and signaling pathways to activate NF-κB/Sox9 axisSemantic proximity Read ↗

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.