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Article

Microenvironment regulation of PRG4 phenotype of chondrocytes.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 May 2007

Blewis Megan E, Schumacher Barbara L, Klein Travis J, Schmidt Tannin A, Voegtline Michael S, Sah Robert L

Abstract excerpt

Articular cartilage is a heterogeneous tissue with superficial (S), middle (M), and deep (D) zones. Chondrocytes in the S zone secrete the lubricating PRG4 protein, while chondrocytes from the M and D zones are more specialized in producing large amounts of the glycosaminoglycan (GAG) component of the extracellular matrix. Soluble and insoluble chemicals and mechanical stimuli regulate cartilage development,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17262831
DOI: 10.1002/jor.20307

Genes

PRG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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