Article
Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation.
Frontiers in immunology - 1 Jan 2020
Indio Valentina, Ravegnini Gloria, Astolfi Annalisa, Urbini Milena, Saponara Maristella, De Leo Antonio, Gruppioni Elisa, Tarantino Giuseppe, Angelini Sabrina, Pession Andrea, Pantaleo Maria Abbondanza, Nannini Margherita
Abstract excerpt
Platelet Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in only about 5-7% of gastrointestinal stromal tumors (GIST), notably with alterations on exons 12/14/18. The most frequent PDGFRA mutation is the exon 18 D842V, which is correlated to specific clinico-pathological features, such as primary imatinib resistance and higher indolence. Here, we present a gene expression profile (GEP) comparison of...
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