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Structural and Biochemical Analyses Reveal that Chlorogenic Acid Inhibits the Shikimate Pathway

8 Jul 2020

Abstract excerpt

The shikimate pathway is an attractive target for the development of herbicides and antimicrobial agents, as it is essential in plants, bacteria, and apicomplexan parasites but absent in humans. The enzymes of shikimate pathway are conserved among bacteria. Thus, the inhibitors of the shikimate pathway act on wide range of pathogens. We have identified that chlorogenic acid targets the enzymes of the shikimate...

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PMID: 32661075
DOI: 10.1128/jb.00248-20

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