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Article

A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding.

Biochemistry - 29 Mar 2011

Light Samuel H, Minasov George, Shuvalova Ludmilla, Peterson Scott N, Caffrey Michael, Anderson Wayne F, Lavie Arnon

Abstract excerpt

Dehydroquinate dehydratase (DHQD) catalyzes the third step in the biosynthetic shikimate pathway. We present three crystal structures of the Salmonella enterica type I DHQD that address the functionality of a surface loop that is observed to close over the active site following substrate binding. Two wild-type structures with differing loop conformations and kinetic and structural studies of a mutant provide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21291284
DOI: 10.1021/bi102020s
PMCID: PMC3062685

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