Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT.

Biochemical and biophysical research communications - 7 Feb 2014

Liu Fabao, You Xiaona, Chi Xiumei, Wang Tao, Ye Lihong, Niu Junqi, Zhang Xiaodong

Abstract excerpt

The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Mice, Nude

Share to Mutant Proteins

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to Viral Regulatory and Accessory Proteins

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 24434140
DOI: 10.1016/j.bbrc.2014.01.004

Genes

PTPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT.PMID 24434140Read ↗

Tumor suppressor micro RNA miR-145 and onco micro RNAs miR-21 and miR-222 expressions are differentially modulated by Hepatitis B virus X protein in malignant hepatocytesSemantic proximity Read ↗

Downregulation of MicroRNA-145 Caused by Hepatitis B Virus X Protein Promotes Expression of CUL5 and Contributes to Pathogenesis of Hepatitis B Virus-Associated Hepatocellular CarcinomaSemantic proximity Read ↗

A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.Semantic proximity Read ↗

Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesisSemantic proximity Read ↗

A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.Semantic proximity Read ↗

Hepatitis B virus X protein activates proteasomal activator 28 gamma expression via upregulation of p53 levels to stimulate virus replicationSemantic proximity Read ↗

HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTENSemantic proximity Read ↗

Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses.Semantic proximity Read ↗

Molecular functions and biological roles of hepatitis B virus x proteinSemantic proximity Read ↗

Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma.Semantic proximity Read ↗

Long non-coding RNA FTX promotes gastric cancer progression by targeting miR-215.Semantic proximity Read ↗

MicroRNA expression profiles of LO2 cells expressing the wild-type and mutant HBx gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.