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Article

HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN

5 Jan 2017

Abstract excerpt

Hepatitis B virus X protein (HBx) is involved in the initiation and progression of hepatocellular carcinoma (HCC). However, the mechanism is still needed to be elucidated. In this study, we explored the relationship between HBx and microRNA and their roles in hepato-carcinogenesis. Firstly, by global microarray-based microRNA profiling and qRT-PCR, we found miR-181a was strongly up-regulated in HepG2.2.15 cells...

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PMID: 28053323
DOI: 10.1038/srep40089

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