Article
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.
Acta pharmacologica Sinica - 1 Mar 2010
Wang Qi, Zhang Wei-ying, Ye Li-hong, Zhang Xiao-dong
Abstract excerpt
AIM: Previously, we identified a natural mutant of hepatitis B virus X gene (HBx) with a deletion from 382 to 401 base pairs (termed HBxDelta127), which could potently enhance growth of hepatoma cells. In this study, we further investigated the mechanism of increased hepatoma cell growth that was mediated by HBxDelta127. METHODS: We examined the effect of HBxDelta127 on the transcription factor sterol regulatory...
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