Article
Lack of association of the p450 oxidoreductase *28 single nucleotide polymorphism with the lipid-lowering effect of statins in hypercholesterolemic patients.
Molecular diagnosis & therapy - 1 Jun 2014
Ragia Georgia, Kolovou Vana, Tavridou Anna, Elens Laure, Tselepis Alexandros D, Elisaf Moses, Van Schaik Ron H N, Kolovou Genovefa, Manolopoulos Vangelis G
Abstract excerpt
BACKGROUND AND OBJECTIVE: Inter-individual variability exists in the statin (HMG-CoA reductase inhibitor) lipid-lowering response, which is partially attributed to genetic factors. The polymorphic enzyme P450 oxidoreductase (POR) transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to cytochrome P450 (CYP) 3A enzymes, which metabolize atorvastatin and simvastatin. The POR*28 allele is...
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