The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila

Abstract excerpt

Abstract Immune and metabolic pathways collectively influence host responses to microbial invaders, and mutations in one pathway frequently disrupt activity in another. We used the Drosophila melanogaster model to characterize metabolic homeostasis in flies with modified immune deficiency (IMD) pathway activity. The IMD pathway is very similar to the mammalian TNF-α pathway, a key regulator of vertebrate immunity...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Insect symbiosis and bacterial influences
• Share to Invertebrate Immune Response Mechanisms
• Share to Mosquito-borne diseases and control