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Article

Pyrin Modulates the Intracellular Distribution of PSTPIP1.

PloS one - 7 Jul 2009

Waite Andrea L, Schaner Philip, Richards Neil, Balci-Peynircioglu Banu, Masters Seth L, Brydges Susannah D, Fox Michelle, Hong Arthur, Yilmaz Engin, Kastner Daniel L, Reinherz Ellis L, Gumucio Deborah L

Abstract excerpt

PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an autoinflammatory disease. PSTPIP1 binds to pyrin and mutations in pyrin result in familial Mediterranean fever (FMF), a related autoinflammatory disorder. Since disease-associated mutations in PSTPIP1...

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Identifiers

PMID: 19584923
DOI: 10.1371/journal.pone.0006147
PMCID: PMC2702820

Genes

PSTPIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pyrin Modulates the Intracellular Distribution of PSTPIP1.PMID 19584923Read ↗

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