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Article

Recent progress in abasic site-binding small molecules for detecting single-base mutations in DNA.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry - 1 Jan 2014

Nishizawa Seiichi, Sato Yusuke, Teramae Norio

Abstract excerpt

This review addresses our recent efforts to design AP site-binding small ligands for SNP (single-nucleotide polymorphisms) typing. First, we present a surface plasmon resonance (SPR) biosensor carrying a derivative of 3,5-diaminopyrazines. Comparison with a bulk assay based on 3,5-diaminopyrazines-DNA binding shows that the immobilization of 3,5-diaminopyrazines on the SPR sensor allows a more sensitive detection...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24420255
DOI: 10.2116/analsci.30.137

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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