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Article

Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2014

Fang Rong, Zheng Chao, Sun Yihua, Han Xiangkun, Gao Bin, Li Chenguang, Liu Hongyan, Wong Kwok-Kin, Liu Xin-Yuan, Chen Haiquan, Ji Hongbin

Abstract excerpt

Liver kinase B1 (LKB1) genetic alteration in lung cancer involves not only point mutations and small deletion of several base pairs but also exonic loss. However, most of recent studies in LKB1 gene status only focus on point mutations and small deletion, and thus may underestimate the actual frequency of LKB1 genetic alteration in lung cancer. Thus, an integrative analysis of LKB1 genetic alteration is timely...

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Identifiers

PMID: 24419424
DOI: 10.1097/JTO.0000000000000056

Genes

EGFR
KRAS
ALK
BRAF
RET
ROS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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