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Article

BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis.

Journal of dental research - 1 May 2017

Wang J, Massoudi D, Ren Y, Muir A M, Harris S E, Greenspan D S, Feng J Q

Abstract excerpt

Mutations in bone morphogenetic protein 1 (BMP1) in humans or deletion of BMP1 and related protease tolloid like 1 (TLL1) in mice lead to osteogenesis imperfecta (OI). Here, we show progressive periodontal defects in mice in which both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal ligament (PDL) (recently shown to play key roles in normal alveolar bone formation), significant loss...

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Share to Extracellular Matrix
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Share to Matrix Metalloproteinase 13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28068493
DOI: 10.1177/0022034516686558
PMCID: PMC5453494

Genes

BMP1
TLL1
DMP1
MMP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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