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Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response

9 Jan 2014

Abstract excerpt

We have generated transgenic mice that harbor humanized type I interferon receptors (IFNARs) enabling the study of type I human interferons (Hu-IFN-Is) in mice. These "HyBNAR" (Hybrid IFNAR) mice encode transgenic variants of IFNAR1 and IFNAR2 with the human extracellular domains being fused to transmembrane and cytoplasmic segments of mouse sequence. B16F1 mouse melanoma cells harboring the HyBNAR construct...

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PMID: 24416207
DOI: 10.1371/journal.pone.0084259

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