Article
Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Solberg Nathan O, Chamberlin Ryan, Vigil Jenette R, Deck Lorraine M, Heidrich John E, Brown David C, Brady Christina I, Vander Jagt Thomas A, Garwood Michael, Bisoffi Marco, Severns Virginia, Vander Jagt David L, Sillerud Laurel O
Abstract excerpt
Alzheimer's disease (AD) is associated with a microglia-dependent neuroinflammatory response against plaques containing the fibrous protein amyloid-β (Aβ). Activation of microglia, which closely associate with Aβ plaques, engenders the release of pro-inflammatory cytokines and the internalization...
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