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Article

Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease.

Current Alzheimer research - 1 Apr 2009

Higuchi Makoto

Abstract excerpt

OBJECTIVES: Microglial overactivation, which is secondary to abnormalities of amyloid-beta peptide (Abeta) and tau proteins in the pathogenic cascade leading to onset of Alzheimer's disease (AD), accelerates tau pathology, according to our recent observations using mouse models of tauopathies, and this positive feedback results in formation of a vicious cycle between upstream and downstream processes, potentially...

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PMID: 19355848
DOI: 10.2174/156720509787602906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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