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Article

The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B.

Scientific reports - 13 Jan 2014

Tsang Ka Hing, Lai Suk King, Li Qi, Yung Wing Ho, Liu Hang, Mak Priscilla Hoi Shan, Ng Cypress Chun Pong, McAlonan Grainne, Chan Ying Shing, Chan Siu Yuen

Abstract excerpt

TSPYL2 is an X-linked gene encoding a nucleosome assembly protein. TSPYL2 interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked mental retardation. As nucleosome assembly and chromatin remodeling are important in transcriptional regulation and neuronal function, we addressed the importance of TSPYL2 through analyzing Tspyl2 loss-of-function mice. We detected down-regulation...

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Identifiers

PMID: 24413569
DOI: 10.1038/srep03654
PMCID: PMC3888966

Genes

TSPYL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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