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Article

Szt2, a novel gene for seizure threshold in mice.

Genes, brain, and behavior - 1 Jul 2009

Frankel W N, Yang Y, Mahaffey C L, Beyer B J, O'Brien T P

Abstract excerpt

In a chemical mutagenesis screen we identified Szt2 (seizure threshold 2) as a gene that confers low seizure threshold to mice and may also enhance epileptogenesis. The semidominant phenotype was mapped to Chromosome 4 and narrowed further to a critical interval of approximately 650 kb. A novel large (> 10 kb) transcript in the critical interval was found to have fourfold increased steady-state expression at the...

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Identifiers

PMID: 19624305
DOI: 10.1111/j.1601-183X.2009.00509.x
PMCID: PMC2728062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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