Article
Critical role for mast cell Stat5 activity in skin inflammation.
Cell reports - 30 Jan 2014
Ando Tomoaki, Xiao Wenbin, Gao Peisong, Namiranian Siavash, Matsumoto Kenji, Tomimori Yoshiaki, Hong Hong, Yamashita Hirotaka, Kimura Miho, Kashiwakura Jun-Ichi, Hata Tissa R, Izuhara Kenji, Gurish Michael F, Roers Axel, Rafaels Nicholas M, Barnes Kathleen C, Jamora Colin, Kawakami Yuko, Kawakami Toshiaki
Abstract excerpt
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Here, we show that phospholipase C-β3 (PLC-β3)-deficient mice spontaneously develop AD-like skin lesions and more severe allergen-induced dermatitis than wild-type mice. Mast cells were required for both AD models and remarkably increased in the skin of Plcb3(-/-) mice because of the increased Stat5 and reduced SHP-1 activities. Mast cell-specific...
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