IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and promotes atopic dermatitis inflammation

Abstract excerpt

<title>Abstract</title> <p>Atopic dermatitis (AD) is a chronic inflammatory skin disorder caused by immune dysregulation that involves the release of various pro-inflammatory cytokines. Patients with AD frequently exhibit basophil infiltration in the affected skin. Although the role of the NLRP3 inflammasome in innate immune cells has been extensively studied, the contribution of the basophil inflammasome to the...

Topics

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• Anti-Inflammatory Agents
• Autoimmunity
• Inflammasomes
• Mice
• Mutation
• NLR Family, Pyrin Domain-Containing 3 Protein
• Polymorphism, Single Nucleotide
• Skin Diseases

Identifiers and source

Literature Corpus work

8178bbde-b1c6-58c2-b408-6910bec62d45

DOI

10.21203/rs.3.rs-6248225/v1