[Pathophysiological aspects of primary Sjögren's disease : From epithelial activation to systemic autoimmunity].

Abstract excerpt

BACKGROUND: Primary Sjögren's disease (SjD) is a chronic autoimmune disease that predominantly affects exocrine glands but can also show numerous systemic organ manifestations. OBJECTIVE: Presentation of the current understanding of the pathogenesis of the disease, focusing on genetic predisposition, epithelial activation, interferon signature and the resulting B‑T cell interaction, which form the basis for...

Topics

• Humans
• Sjogren's Syndrome
• Autoimmunity
• Epithelial Cells
• Models, Immunological
• Immunity, Innate
• Genetic Predisposition to Disease