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Article

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge.

Blood - 23 Nov 2017

Latour Chloé, Besson-Fournier Céline, Gourbeyre Ophélie, Meynard Delphine, Roth Marie-Paule, Coppin Hélène

Abstract excerpt

Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males. This is consistent with the current views that HJV is a coreceptor for BMP6 in hepatocytes. To determine whether BMP6 and HJV may also signal to hepcidin independently of each other, we...

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Source

Identifiers

PMID: 29021231
DOI: 10.1182/blood-2017-07-795658

Genes

BMP6
HJV
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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