Article
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
PloS one - 1 Jan 2013
Kauder Steven E, Santell Lydia, Mai Elaine, Wright Lilyan Y, Luis Elizabeth, N'Diaye Elsa N, Lutman Jeff, Ratti Navneet, Sa Susan M, Maun Henry R, Stefanich Eric, Gonzalez Lino C, Graham Robert R, Diehl Lauri, Faubion William A, Keir Mary E, Young Judy, Chaudhuri Amitabha, Lazarus Robert A, Egen Jackson G
Abstract excerpt
BACKGROUND: Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility to both Crohn's disease and ulcerative colitis, two major types of inflammatory bowel disease (IBD) characterized by chronic inflammation of the digestive...
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