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Article

Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease.

The Journal of clinical investigation - 15 Dec 1998

Foster C B, Lehrnbecher T, Mol F, Steinberg S M, Venzon D J, Walsh T J, Noack D, Rae J, Winkelstein J A, Curnutte J T, Chanock S J

Abstract excerpt

Chronic granulomatous disease (CGD) is an inherited disorder of phagocyte function in which defective superoxide production results in deficient microbicidal activity. CGD patients suffer from recurrent, life-threatening infections, and nearly half develop chronic gastrointestinal (GI) complications (colitis, gastric outlet obstruction, or perirectal abscess) and/or autoimmune/rheumatologic disorders (AIDs). To...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9854050
DOI: 10.1172/JCI5084
PMCID: PMC509169

Genes

MPO
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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