Article
Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease.
The Journal of clinical investigation - 15 Dec 1998
Foster C B, Lehrnbecher T, Mol F, Steinberg S M, Venzon D J, Walsh T J, Noack D, Rae J, Winkelstein J A, Curnutte J T, Chanock S J
Abstract excerpt
Chronic granulomatous disease (CGD) is an inherited disorder of phagocyte function in which defective superoxide production results in deficient microbicidal activity. CGD patients suffer from recurrent, life-threatening infections, and nearly half develop chronic gastrointestinal (GI) complicati...
Topics
- Autoimmune Diseases
- Carrier Proteins
- Collectins
- Cytokines
- Female
- Genotype
- Granulomatous Disease, Chronic
- Humans
- Immunity
- Male
- Peroxidase
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, IgG