Article
Pentraxins and IgA share a binding hot-spot on FcαRI.
Protein science : a publication of the Protein Society - 1 Apr 2014
Lu Jinghua, Marjon Kristopher D, Mold Carolyn, Marnell Lorraine, Du Clos Terry W, Sun Peter
Abstract excerpt
The pentraxins, C-reactive protein (CRP), and serum amyloid P component (SAP) have previously been shown to function as innate opsonins through interactions with Fcγ receptors. The molecular details of these interactions were elucidated by the crystal structure of SAP in complex with FcγRIIA. More recently, pentraxins were shown to bind and activate FcαRI (CD89), the receptor for IgA. Here, we used mutations of...
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