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Article

Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.

Nature - 20 Jul 2000

Garman S C, Wurzburg B A, Tarchevskaya S S, Kinet J P, Jardetzky T S

Abstract excerpt

The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilonRI. Crosslinking of Fc epsilonRI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. The interaction of the crystallizable fragment (Fc) of IgE (IgE-Fc) with Fc epsilonRI is a key recognition event of...

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Share to Antibody Specificity
Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10917520
DOI: 10.1038/35018500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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