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Article

BACE1 activity regulates cell surface contactin-2 levels

9 Jan 2014

Abstract excerpt

BACKGROUND: Although BACE1 is a major therapeutic target for Alzheimer's disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-mediated cleavage of human contactin-2, a GPI-anchored cell adhesion molecule. RESULTS: Our initial protein sequence...

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PMID: 24405708
DOI: 10.1186/1750-1326-9-4

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