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Article

Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.

The Journal of biological chemistry - 21 Feb 2014

Szabó András, Radisky Evette S, Sahin-Tóth Miklós

Abstract excerpt

Human cationic trypsinogen, precursor of the digestive enzyme trypsin, can be rapidly degraded to protect the pancreas when pathological conditions threaten, while trypsin itself is impressively resistant to degradation. For either form, degradation is controlled by two necessary initial proteolytic events: cleavage of the Leu81-Glu82 peptide bond by chymotrypsin C (CTRC) and cleavage of the Arg122-Val123 peptide...

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Identifiers

PMID: 24403079
DOI: 10.1074/jbc.M113.538884
PMCID: PMC3931037

Genes

CTRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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