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Article

High-affinity Ca(2+) binding inhibits autoactivation of rat trypsinogen.

Biochemical and biophysical research communications - 28 Aug 2000

Sahin-Tóth M, Tóth M

Abstract excerpt

The recent discovery that mutation Asn21 --> Ile in the human cationic trypsinogen (Tg) is associated with hereditary pancreatitis has brought into focus the functional role of amino acid 21 in mammalian Tgs. In the present paper, the effect of mutations Thr21 --> Asn and Thr21 --> Ile on the Ca(2+) dependence of zymogen activation was investigated, using the autolysis-resistant rat Tg mutant Arg117 --> His. In...

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Identifiers

PMID: 10964720
DOI: 10.1006/bbrc.2000.3355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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