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Article

Evolution of trypsinogen activation peptides.

Molecular biology and evolution - 1 Nov 2003

Chen Jian-Min, Kukor Zoltán, Le Maréchal Cédric, Tóth Miklós, Tsakiris Laurent, Raguénès Odile, Férec Claude, Sahin-Tóth Miklós

Abstract excerpt

The activation peptide of mammalian trypsinogens contains a highly conserved tetra-aspartate sequence (D19-D20-D21-D22) preceding the K23-I24 scissile peptide bond, which is hydrolyzed as the first step in the activation process. Here, we examined the evolution and function of trypsinogen activation peptides through integrating functional characterization of disease-associated mutations with comparative genomic...

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Identifiers

PMID: 12832630
DOI: 10.1093/molbev/msg183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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