Article
Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.
EMBO molecular medicine - 1 Feb 2014
Huijbers Ivo J, Bin Ali Rahmen, Pritchard Colin, Cozijnsen Miranda, Kwon Min-Chul, Proost Natalie, Song Ji-Ying, de Vries Hilda, Badhai Jitendra, Sutherland Kate, Krimpenfort Paul, Michalak Ewa M, Jonkers Jos, Berns Anton
Abstract excerpt
Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular basis of tumor development and enable testing of new intervention strategies. The inherent complexity of these models, with often multiple modified tumor suppressor genes and oncogenes, has hampered their use as preclinical models for validating cancer genes and drug targets. In our...
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