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Harnessing preclinical mouse models to inform human clinical cancer trials

23 Mar 2006

Abstract excerpt

The urgent need for better cancer treatments has stimulated interest in employing small-animal models to evaluate potential drug therapies. Robust mouse models of many human cancers have been generated using sophisticated technologies for engineering germ-line mutations. As we enter into an age of targeted therapeutics, these strains provide novel platforms for validating new anticancer drugs, assessing...

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PMID: 16585951
DOI: 10.1172/jci28271

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