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Article

A phenotypic change but not proliferation underlies glial responses in Alzheimer disease.

The American journal of pathology - 1 Jun 2013

Serrano-Pozo Alberto, Gómez-Isla Teresa, Growdon John H, Frosch Matthew P, Hyman Bradley T

Abstract excerpt

Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial reactions, but whether this pathological feature is due primarily to cell proliferation or to a phenotypic change of existing resting cells remains controversial. We performed double-fluorescence immunohistochemical studies of astrocytes and microglia, followed by unbiased stereology-based quantitation in temporal...

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Identifiers

PMID: 23602650
DOI: 10.1016/j.ajpath.2013.02.031
PMCID: PMC3668030

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GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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