Article
Dietary acrylamide intake and the risk of colorectal cancer with specific mutations in KRAS and APC.
Carcinogenesis - 1 May 2014
Hogervorst Janneke G F, de Bruijn-Geraets Daisy, Schouten Leo J, van Engeland Manon, de Kok Theo M C M, Goldbohm R Alexandra, van den Brandt Piet A, Weijenberg Matty P
Abstract excerpt
Acrylamide, a probable human carcinogen, is present in heat-treated carbohydrate-rich foods. Epidemiological studies have not shown a clear association between acrylamide intake and colorectal cancer (CRC) risk. This may be due to the molecular heterogeneity in colorectal tumors, which was not taken into consideration before. Since the acrylamide metabolite glycidamide induces specific DNA mutations in rodents,...
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