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Article

Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Nakagawa Hayato, Hikiba Yohko, Hirata Yoshihiro, Font-Burgada Joan, Sakamoto Kei, Hayakawa Yoku, Taniguchi Koji, Umemura Atsushi, Kinoshita Hiroto, Sakitani Kosuke, Nishikawa Yuji, Hirano Kenji, Ikenoue Tsuneo, Ijichi Hideaki, Dhar Debanjan, Shibata Wataru, Akanuma Masao, Koike Kazuhiko, Karin Michael, Maeda Shin

Abstract excerpt

E-cadherin is an important adhesion molecule whose loss is associated with progression and poor prognosis of liver cancer. However, it is unclear whether the loss of E-cadherin is a real culprit or a bystander in liver cancer progression. In addition, the precise role of E-cadherin in maintaining liver homeostasis is also still unknown, especially in vivo. Here we demonstrate that liver-specific E-cadherin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholangitis, Sclerosing

Share to Epithelial-Mesenchymal Transition

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Source

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Identifiers

PMID: 24395807
DOI: 10.1073/pnas.1322731111
PMCID: PMC3903249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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