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Article

Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis

11 Oct 2017

Abstract excerpt

β-Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic development, regeneration, and tumorigenesis. However, its role at hepatocyte adherens junctions (AJ) is relatively poorly understood, chiefly due to spontaneous compensation by γ-catenin. We simultaneously ablated β- and γ-catenin expression in mouse liver by interbreeding β-catenin-γ-catenin double-floxed mice and Alb-Cre...

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PMID: 29023813
DOI: 10.1002/hep.29585

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