Article
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Cell reports - 29 Jun 2021
Martirosian Vahan, Deshpande Krutika, Zhou Hao, Shen Keyue, Smith Kyle, Northcott Paul, Lin Michelle, Stepanosyan Vazgen, Das Diganta, Remsik Jan, Isakov Danielle, Boire Adrienne, De Feyter Henk, Hurth Kyle, Li Shaobo, Wiemels Joseph, Nakamura Brooke, Shao Ling, Danilov Camelia, Chen Thomas, Neman Josh
Abstract excerpt
Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum. Although abnormal GABAergic receptor activation has been described in MB, studies have not yet elucidated the contribution of receptor-independent GABA metabolism to MB pathogenesis. We find primary MB tumors globally display decreased expression of GABA transaminase (ABAT), the protein responsible for GABA metabolism, compared...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.