Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca2+-NFAT1 Axis

19 Dec 2018

Abstract excerpt

Basal-like breast cancer (BLBC) is the most aggressive subtype with a poor clinical outcome; however, the molecular mechanisms underlying aggressiveness in BLBC remain poorly understood. Methods: The effects of gamma-aminobutyrate aminotransferase (ABAT) on GABA receptors, Ca 2+ -NFAT1 axis, and cancer cell behavior were assessed by Ca 2+ imaging, Western blotting, immunostaining, colony formation, and migration...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30662552
DOI: 10.7150/thno.29407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca2+-NFAT1 AxisPMID 30662552Read ↗

GABA(A) Receptor Pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration through Activation of Extracellular-regulated Kinase 1/2 (ERK1/2)Semantic proximity Read ↗

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cellsSemantic proximity Read ↗

Downregulation of GLYAT facilities tumor growth and metastasis and poor clinical outcomes through the PI3K/AKT/Snail pathway in human breast cancerSemantic proximity Read ↗

GABRQ is Overexpressed and Correlated with Tumor Progression in Breast CancerSemantic proximity Read ↗

GABAergic signaling contributes to tumor cell invasion and poor overall survival in colorectal cancerSemantic proximity Read ↗

The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer modelsSemantic proximity Read ↗

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12Semantic proximity Read ↗

The Oncogenic Role of γ-Aminobutyrate Aminotransferase in Human Tumor: A Pan-Cancer AnalysisSemantic proximity Read ↗

Investigation into the Association between Neurotransmitters, Immune Features, and Lung Adenocarcinoma: A Multi-Omics Approach to the Identification of GABA-Related Features Employing 101 Combinatorial Machine Learning Computational FrameworksSemantic proximity Read ↗

AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-κB signaling pathwaySemantic proximity Read ↗

Epithelial-to-mesenchymal transition activates Bcat1 expression to promote recurrent tumor growthSemantic proximity Read ↗

Differential expression and prognostic relevance of autophagy-related markers ATG4B, GABARAP, and LC3B in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.