Article
Integrative genomic analysis identifies a role for intercellular adhesion molecule 1 in childhood asthma.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Mar 2014
Klaassen Ester M M, van de Kant Kim D G, Jöbsis Quirijn, Penders John, van Schooten Frederik Jan, Quaak Marieke, den Hartog Gertjan J M, Koppelman Gerard H, van Schayck Constant P, van Eys Guillaume, Dompeling Edward
Abstract excerpt
BACKGROUND: Childhood asthma is characterized by chronic airway inflammation. Integrative genomic analysis of airway inflammation on genetic and protein level may help to unravel mechanisms of childhood asthma. We aimed to employ an integrative genomic approach investigating inflammation markers on DNA, mRNA, and protein level at preschool age in relationship to asthma development. METHODS: In a prospective...
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