Article
Multi-ancestry genome-wide association study of asthma exacerbations.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Jun 2022
Herrera-Luis Esther, Ortega Victor E, Ampleford Elizabeth J, Sio Yang Yie, Granell Raquel, de Roos Emmely, Terzikhan Natalie, Vergara Ernesto Elorduy, Hernandez-Pacheco Natalia, Perez-Garcia Javier, Martin-Gonzalez Elena, Lorenzo-Diaz Fabian, Hashimoto Simone, Brinkman Paul, Jorgensen Andrea L, Yan Qi, Forno Erick, Vijverberg Susanne J, Lethem Ryan, Espuela-Ortiz Antonio, Gorenjak Mario, Eng Celeste, González-Pérez Ruperto, Hernández-Pérez José M, Poza-Guedes Paloma, Sardón Olaia, Corcuera Paula, Hawkins Greg A, Marsico Annalisa, Bahmer Thomas, Rabe Klaus F, Hansen Gesine, Kopp Matthias Volkmar, Rios Raimon, Cruz Maria Jesus, González-Barcala Francisco-Javier, Olaguibel José María, Plaza Vicente, Quirce Santiago, Canino Glorisa, Cloutier Michelle, Del Pozo Victoria, Rodriguez-Santana Jose R, Korta-Murua Javier, Villar Jesús, Potočnik Uroš, Figueiredo Camila, Kabesch Michael, Mukhopadhyay Somnath, Pirmohamed Munir, Hawcutt Daniel B, Melén Erik, Palmer Colin N, Turner Steve, Maitland-van der Zee Anke H, von Mutius Erika, Celedón Juan C, Brusselle Guy, Chew Fook Tim, Bleecker Eugene, Meyers Deborah, Burchard Esteban G, Pino-Yanes Maria
Abstract excerpt
BACKGROUND: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. We aimed to...
Topics
- Asthma
- Genetic Predisposition to Disease