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Article

Early neutrophil and persistent eosinophil-associated gene signature in childhood asthma.

American journal of respiratory and critical care medicine - 1 Jun 2026

Foppiano Francesco, Böck Andreas, Beerweiler Claudia, Urner Kathrin, Ege Markus, Schmausser-Hechfellner Elisabeth, Skevaki Chrysanthi, Frey Urs, Riedler Josef, Frei Remo, Lauener Roger, Roduit Caroline, Karvonen Anne M, Roponen Marjut, Pekkanen Juha, Divaret-Chauveau Amandine, Barnig Cindy, Von Mutius Erika, Schaub Bianca

Abstract excerpt

RATIONALE: Early childhood represents a critical window for asthma susceptibility, marked by developmental and molecular changes, yet their longitudinal pattern remains unclear. OBJECTIVES: To identify differences in longitudinal whole-blood gene expression during early childhood in future asthmatics compared to healthy children. METHODS: We conducted a longitudinal whole-blood transcriptomic analysis at 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42085277
DOI: 10.1093/ajrccm/aamag142
PMCID: PMC13253034

Genes

GSDMB
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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