Article
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing.
eLife - 25 May 2023
Granell Raquel, Curtin John A, Haider Sadia, Kitaba Negusse Tadesse, Mathie Sara A, Gregory Lisa G, Yates Laura L, Tutino Mauro, Hankinson Jenny, Perretti Mauro, Vonk Judith M, Arshad Hasan S, Cullinan Paul, Fontanella Sara, Roberts Graham C, Koppelman Gerard H, Simpson Angela, Turner Steve W, Murray Clare S, Lloyd Clare M, Holloway John W, Custovic Adnan
Abstract excerpt
Background: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of 'doctor-diagnosed asthma', thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes. Methods: We conducted a novel multivariate GWAS...
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