Article

Non-oncology drugs are a source of previously unappreciated anti-cancer activity

2019-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Anti-cancer uses of non-oncology drugs have been found on occasion, but such discoveries have been serendipitous and rare. We sought to create a public resource containing the growth inhibitory activity of 4,518 drugs tested across 578 human cancer cell lines. To accomplish this, we used PRISM, which involves drug treatment of molecularly barcoded cell lines in pools. Relative barcode abundance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d16282a-14ad-52e9-822c-b7d809c07277
DOI: 10.1101/730119

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-oncology drugs are a source of previously unappreciated anti-cancer activityDOI 10.1101/730119Read

Safeguarding COVID-19 and cancer management: drug design and therapeutic approachSemantic proximity Read

MUSTARD-a comprehensive resource of mutation-specific therapies in cancer.Semantic proximity Read

Systematic functional drug testing in patient-derived models reveals ex vivo sensitivities associated with clinical outcome in rare solid tumorsSemantic proximity Read

Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncologySemantic proximity Read

Potential Reuse of Oncology Drugs in the Treatment of Rare Diseases.Semantic proximity Read

Drug discovery and repurposing at Memorial Sloan Kettering Cancer Center: chemical biology drives translational medicine.Semantic proximity Read

Molecular Target and Action Mechanism of Anti-Cancer AgentsSemantic proximity Read

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological TargetsSemantic proximity Read

A single-cell atlas of DKD treatment responses.Semantic proximity Read

Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA ExpressionSemantic proximity Read

The landscape of drug sensitivity and resistance in sarcomaSemantic proximity Read

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.Semantic proximity Read