Article
The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.
PLoS genetics - 1 Jan 2014
Moayedi Yalda, Basch Martin L, Pacheco Natasha L, Gao Simon S, Wang Rosalie, Harrison Wilbur, Xiao Ningna, Oghalai John S, Overbeek Paul A, Mardon Graeme, Groves Andrew K
Abstract excerpt
The Notch signaling pathway is thought to regulate multiple stages of inner ear development. Mutations in the Notch signaling pathway cause disruptions in the number and arrangement of hair cells and supporting cells in sensory regions of the ear. In this study we identify an insertional mutation in the mouse Sfswap gene, a putative splicing factor, that results in mice with vestibular and cochlear defects that...
Topics
- Alternative Splicing
- Animals
- Body Patterning
- Calcium-Binding Proteins
- Cochlea
- Ear, Inner
- Hair Cells, Auditory, Inner
- Intercellular Signaling Peptides and Proteins
- Jagged-1 Protein
- Membrane Proteins
- Mice
- Mutation
- RNA Splicing Factors