Article
Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.
Cancer research - 1 Jan 2008
Tuupanen Sari, Niittymäki Iina, Nousiainen Kari, Vanharanta Sakari, Mecklin Jukka-Pekka, Nuorva Kyösti, Järvinen Heikki, Hautaniemi Sampsa, Karhu Auli, Aaltonen Lauri A
Abstract excerpt
A common single nucleotide polymorphism (SNP), rs6983267, at 8q24.21 has recently been shown to associate with colorectal cancer (CRC). Three independent SNP association studies showed that rs6983267 contributes to CRC with odds ratios (OR) of 1.17 to 1.22. Here, we genotyped a population-based s...
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