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Article

Simple and rapid detection of HLA-A*31:01 for prediction of carbamazepine-induced hypersensitivity using loop-mediated isothermal amplification method.

Journal of dermatological science - 1 Apr 2014

Niihara Hiroyuki, Kohno Kunie, Taketani Takeshi, Kaneko Sakae, Ito Takafumi, Sugamori Takashi, Takahashi Nobuyuki, Miyaoka Tuyoshi, Okazaki Shihoh, Yasuda Hideaki, Furuya Motohide, Nagahama Michiharu, Morita Eishin

Abstract excerpt

BACKGROUND: Carbamazepine (CBZ), which is widely used in management of epilepsy or neuropathic pain, causes fatal severe cutaneous adverse reactions (SCARs). CBZ-induced SCARs are known to occur in strong association with human leukocyte antigen (HLA)-A*31:01 in Japanese and European populations. HLA genotyping is currently used to detect human HLA-A*31:01. OBJECTIVE: To establish a simple and rapid screening...

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PMID: 24388047
DOI: 10.1016/j.jdermsci.2013.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Simple and rapid detection of HLA-A*31:01 for prediction of carbamazepine-induced hypersensitivity using loop-mediated isothermal amplification method.PMID 24388047Read ↗

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