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Article

Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of α4β7 integrin.

Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2013

Etemad Behzad, Gonzalez Oscar A, McDonough Sean, Pena-Cruz Victor, Sagar Manish

Abstract excerpt

It has been postulated that HIV-1 envelope properties, such as shorter and less-glycosylated V1-V2 loops commonly observed among non-subtype B early-transmitted viruses, promote utilization of the gut homing integrin α4β7. This property potentially confers an advantage to some HIV-1 variants early after acquisition. We found that replication-competent recombinant viruses incorporating HIV-1 subtype A compact and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23797693
DOI: 10.1097/QAI.0b013e3182a06ddd
PMCID: PMC3800220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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