Article
Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death.
Current biology : CB - 9 Jul 2002
Cohen-Salmon Martine, Ott Thomas, Michel Vincent, Hardelin Jean Pierre, Perfettini Isabelle, Eybalin Michel, Wu Tao, Marcus Daniel C, Wangemann Philine, Willecke Klaus, Petit Christine
Abstract excerpt
Mutations in the gene encoding the gap junction protein connexin26 (Cx26) are responsible for the autosomal recessive isolated deafness, DFNB1, which accounts for half of the cases of prelingual profound hereditary deafness in Caucasian populations. To date, in vivo approaches to decipher the role of Cx26 in the inner ear have been hampered by the embryonic lethality of the Cx26 knockout mice. To overcome this...
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